Best Pizza in Syracuse NY (Updated Jan 2023)

From thin crust to thick, classic Italian style to unique gourmet creations, I got the chance to sample 11 different pizzas and find out which is the best.

I’m a bit of a pizza snob and I’ve had the pleasure of enjoying some amazing pies all over the world. So I was very interested in sampling what Syracuse has to offer.

But how do these local slices stack up against each other? Have a look to find out! Be warned though, this article may have you craving for some cheesy goodness before you even reach the end.

If you don’t find the best pizza here, check out the best pizza in the whole state of New York

#1 best pizza place in Syracuse - Apizza Regionale

#1 Apizza Regionale

Open Hours
Monday: Closed
Tuesday: 11:30AM-3PM,5-9PM
Wednesday: 11:30AM-3PM,5-9PM
Thursday: 11:30AM-3PM,5-9PM
Friday: 11:30AM-3PM,5-9PM
Saturday: 4-9PM
Sunday: 4-9PM

Benefits
  • Has insanely good dessert
  • Has some vegetarian options
  • Serves alcohol (and hard liquor!)
  • Nice tourist spot

Downsides
  • No delivery


As soon as I stepped through the doors, I could tell that this was going to be a good experience. The server was friendly and the atmosphere was relaxed and inviting.

The menu looks great with several vegetarian options, which is always nice for me. But what really stood out were the boozy drinks – beer, wine, and even hard liquor! What a pleasant surprise.

My pizza came out hot and fresh – this joint knows how to make a pizza! The crust was thin but not too thin – just the way I like it. The toppings were fresh and flavorful – definitely some of the best I’ve ever had. If pizza isn’t your thing, they also offer tasty salads and other Italian dishes.

For dessert, Apizza Regionale really shines – get ready for some insanely good treats! They have all levels of sweet satisfaction from classic favorites to house-made indulgent creations. Highly recommend getting something sweet after your meal.

If there’s one thing Apizza Regionale doesn’t do is delivery – so you’ll have to come into their restaurant in Syracuse NY if you want to enjoy their delicious food. But trust me, it’s worth it! All in all this place will blow your taste buds away with some of the best pizza in Syracuse NY!

If you’re willing to go an extra 6 miles, you can get to 30 more pizza places in West New York!

#1 best pizza place in Syracuse - A Mano Kitchen & Bar

#2 A Mano Kitchen & Bar

Open Hours
Monday: Closed
Tuesday: Closed
Wednesday: 4:30-9PM
Thursday: 4:30-9PM
Friday: 4:30-9PM
Saturday: 4:30-9PM
Sunday: Closed

Benefits
  • Has some vegetarian options
  • Has insanely good dessert
  • Serves alcohol (and hard liquor!)
  • Nice tourist spot

Downsides
  • No delivery


I was immediately impressed with the atmosphere of the restaurant. The waitstaff was friendly and the atmosphere was lively, making it a great tourist spot.

The menu had some great options for everyone in my party, including vegetarians and those who wanted to imbibe in an alcoholic beverage or two (including hard liquor!).

But really, it all comes down to the food – which did not disappoint! The pizzas were simply divine. It was cooked to perfection and you could tell that every ingredient had been carefully chosen. It is clear why this place is one of the most popular pizza places in town!

The only downside with A Mano Kitchen & Bar: no delivery service available. But if you have time to enjoy it there, I highly recommend it. Plus, don’t forget to save room for dessert – they have some insanely good treats!

#1 best pizza place in Syracuse - Pavone's Pizza - Syracuse, NY

#3 Pavone’s Pizza – Syracuse, NY


Benefits
  • Nice tourist spot


The atmosphere of Pavone’s is fantastic. It has a family-friendly vibe and the staff are really friendly, always willing to make sure that your meal is perfect. I’ve been lucky enough to sample some of their signature pies and they did not disappoint.

The Margherita pizza was truly divine – the San Marzano tomatoes were perfectly cooked, the cheese stretched out like velvet, and the basil gave it a fresh herbaceous finish. The crust is light and crisp with just the right amount of chewiness.

If you’re looking for something a bit more adventurous, then I highly recommend their Prosciutto Arugula Pizza – tender slices of prosciutto combined with freshly picked arugula and melted fontina cheese, all on top of an incredible garlic-infused crust. It will transport you to foodie heaven!

Pavone’s also serves up some delicious appetizers and salads. Their fried calamari with spicy marinara is beyond delicious, as is their antipasto salad that features salami, capicola ham, provolone cheese, fermented vegetables, pickled peppers and artichokes.

To sum it up: Pavone’s Pizza – Syracuse NY has some of the best pizza in Syracuse NY! The atmosphere is great; the staff are very helpful; and the pizzas are made to perfection with quality ingredients sourced from local farms. If you’re ever in town looking for a great pizza experience then Pavone’s should be your first port of call!

#1 best pizza place in Syracuse - Nick's Tomato Pie

#4 Nick’s Tomato Pie

Open Hours
Monday: 11AM-8PM
Tuesday: 11AM-8PM
Wednesday: 11AM-8PM
Thursday: 11AM-1AM
Friday: 11AM-2:30AM
Saturday: 5PM-2:30AM
Sunday: Closed

Benefits
  • Nice tourist spot
  • Has some vegetarian options


As soon as I walked in, I knew I was in for a treat. The smell of the fresh dough and juicy tomatoes wafting through the air was enough to make my mouth water. Once I ordered my favorite combination – mozzarella, pepperoni and roasted peppers – it arrived at my table piping hot.

The texture and flavor were simply out of this world! The crust was perfectly cooked so it held up to all the delicious toppings, while still being light and fluffy in the center. The mushrooms added great earthiness to the pizza, while the pepperoni gave it a nice spicy kick. And that roasted pepper…my gosh! It was sweet yet had just a hint of bitterness that sent my taste buds into overdrive.

Overall, this pizza on its own is enough to make me come back again and again; however, Nick’s Tomato Pie also has some of the best sides too! Their garlic bread was flavorful and crunchy on the outside with a pillowy soft center – just divine! Their salads have always been fresh and never soggy – definitely recommended to get your veggies in before indulging your pizza cravings.

If you’re ever looking for top notch pizza in Syracuse NY, look no further than Nick’s Tomato Pie! With their attention to detail in every bite and outstanding flavors all around, you won’t regret it!

#1 best pizza place in Syracuse - Mario & Salvo's Pizzeria

#5 Mario & Salvo’s Pizzeria

Open Hours
Monday: 10:30AM-8:30PM
Tuesday: 10:30AM-8:30PM
Wednesday: 10:30AM-8:30PM
Thursday: 10:30AM-8:30PM
Friday: 10:30AM-8:30PM
Saturday: 10:30AM-8:30PM
Sunday: 10:30AM-8:30PM

Benefits
  • Nice tourist spot


From the moment I stepped inside, I knew this place was special. The aroma of freshly-baked pizza dough filled the air, and the walls are decorated with Mario & Salvo’s proudly displayed reviews.

On my first visit, I ordered a classic pepperoni pizza and it was absolutely delicious. The mouth-watering combination of spicy pepperoni, melted cheese and thin crust satisfied my taste buds in a way few other places have been able to do.

The friendly atmosphere at Mario & Salvo’s only adds to its charm. Not only did my server make me feel right at home, but the entire staff made sure that my dining experience was top-notch.

At the end of my meal, I can confidently say that Mario & Salvo’s Pizzeria has some of the best pizza in Syracuse NY. Whether you’re looking for a quick bite or an evening out with family and friends, this is definitely the place to go!

#1 best pizza place in Syracuse - Little Mac's Pizzeria

#6 Little Mac’s Pizzeria

Open Hours
Monday: Closed
Tuesday: Closed
Wednesday: 4-9PM
Thursday: 4-9PM
Friday: 3-10PM
Saturday: 3-10PM
Sunday: 3-9PM

From the moment I walked in, I was immediately impressed. The atmosphere is cozy and inviting with an interesting decor that made me feel right at home.

The first thing I noticed was the smell of freshly baked dough coming from the ovens. I could tell they take pride in the ingredients they use to make their pizza because the aroma was nothing like anything I’ve ever experienced before!

When ordering my pizza, I chose a classic combo – pepperoni and cheese – which really let the flavor of their homemade sauce shine through. The crust was perfectly crispy on the outside while staying soft and fluffy on the inside. And as for the toppings, flavourful and plentiful were two words that came to mind.

All in all, Little Mac’s Pizzeria serves up some of the best pizza in Syracuse NY and you’ll definitely be back for more once you try it!

#1 best pizza place in Syracuse - Di Lauro's Bakery and Pizza

#7 Di Lauro’s Bakery and Pizza

Open Hours
Monday: 7AM-5PM
Tuesday: 7AM-5PM
Wednesday: 7AM-5PM
Thursday: 7AM-5PM
Friday: 7AM-5PM
Saturday: 7AM-4PM
Sunday: 7AM-4PM

Benefits
  • Has some vegetarian options


I mean, just look at the pizza. It’s crust is perfectly thin and crispy, with a hint of garlic that makes it all the more savory. The sauce has a great balance of sweet and tart, making for some really tasty slices. As for the toppings? Let’s just say they don’t skimp out on them! Whether you’re into pepperoni or something even more exotic like artichoke hearts, you’ll be sure to find what you’re looking for here.

And that’s not all. The atmosphere of the restaurant is also top-notch. The interior is adorned with bright colors and old-fashioned Italian charm, while the friendly staff further add to the great experience I had there.

In short: if you’re ever in Syracuse NY, be sure to check out Di Lauro’s Bakery and Pizza. You won’t regret it!

#1 best pizza place in Syracuse - Varsity Pizza Syracuse

#8 Varsity Pizza Syracuse

Open Hours
Monday: Closed
Tuesday: 8AM-7PM
Wednesday: 8AM-7PM
Thursday: Closed
Friday: Closed
Saturday: Closed
Sunday: Closed

Benefits
  • Great place to watch sports
  • Has some vegetarian options
  • Serves alcohol
  • Offers dessert
  • Has a kid’s menu
  • Nice tourist spot


The first thing that struck me as soon as I stepped inside the restaurant was its friendly atmosphere – the staff were all incredibly welcoming and hospitable. In fact, the owner even made sure to offer me his best slice of pizza for free!

But on to the pizza itself – it was exquisite! The crust was slightly crispy, but still doughy enough to make it soft and delicious. The sauce had a perfect balance of sweetness and spice, with just enough herbs added in to give it a kick. The cheese was gooey and flavorful, while the toppings (I chose pepperoni and mushrooms) added just the right amount of flavor.

Overall, I’m very impressed with Varsity Pizza Syracuse. Not only did they provide an inviting atmosphere, but they also make some of the best pizza in Syracuse NY. Whether you’re looking for a quick bite or a full meal with friends, Varsity Pizza Syracuse is definitely worth checking out!

If you’re willing to go an extra 32 miles, you can get to 12 more pizza places in Cortland!

#1 best pizza place in Syracuse - Tangy Tomato

#9 Tangy Tomato

Open Hours
Monday: 11AM-9PM
Tuesday: 11AM-9PM
Wednesday: 11AM-9PM
Thursday: 11AM-9PM
Friday: 11AM-10PM
Saturday: 12-10PM
Sunday: Closed

Benefits
  • Offers dessert


The dough was light, crispy and had the perfect balance of sweetness and chewiness. The sauce itself was tangy, with just the right amount of tomato kick. It was obvious that they used top-notch ingredients – it’s nice to know my money is going towards quality!

To top it off, their selection of toppings was vast and varied. Whether you wanted pepperoni, veggies or some more daring options like anchovies or artichokes, they had it covered. I can only imagine what a pizza Christmas tree with all these toppings would look like – probably delicious!

The ambiance at Tangy Tomato adds an extra element of fun to your meal. The walls are adorned with pizza paraphernalia, and you can even order a “pizza card” for your next visit for discounts on certain menu items. There’s also a cool arcade area where you can play classic video games while you wait for your pizza. Overall, this place really knows how to make its customers feel at home!

If you’re looking for great pizza in Syracuse NY (or anywhere else), look no further than Tangy Tomato! It has become one of my favorite places to get pizzas during my travels, and I highly recommend it!

#1 best pizza place in East Syracuse - Pavone's Pizza & Eatery

#10 Pavone’s Pizza & Eatery

Open Hours
Monday: 11AM-9PM
Tuesday: 11AM-9PM
Wednesday: 11AM-9PM
Thursday: 11AM-9PM
Friday: 11AM-10PM
Saturday: 11AM-10PM
Sunday: 12-9PM

Benefits
  • Nice tourist spot
  • Has some vegetarian options


When I walked in to the restaurant, the first thing that caught my eye were the numerous awards they have won over the years. It was clear that Pavone’s is a well-recognized establishment for great pizza!

I decided to order their signature pie, and let me tell you – it didn’t disappoint. The dough was light and fluffy, with just the perfect amount of crunch when I bit into it. The sauce had a sweet tanginess to it that was incredibly delicious, and paired perfectly with the layer of cheese melted on top of it.

What really set this pizza apart from others was its topping selection. Each one of their pizzas comes with an assortment of three toppings – and trust me when I say this – their selection will knock your socks off! Every ingredient is fresh and flavorful; every bite packed a punch of flavor that gave my taste buds an incredible surprise.

All in all, Pavone’s Pizza & Eatery is hands down the best pizza joint in Syracuse NY! If you’re ever looking for some amazing Italian cuisine, then head to Pavone’s – you won’t be disappointed!

#1 best pizza place in Syracuse - Twin Trees Restaurant

#11 Twin Trees Restaurant

Open Hours
Monday: Closed
Tuesday: 4-9PM
Wednesday: 4-9PM
Thursday: 4-9PM
Friday: 4-9PM
Saturday: 4-9PM
Sunday: 4-8PM

Benefits
  • Serves alcohol (and hard liquor!)
  • Offers dessert
  • Nice tourist spot
  • Great place to watch sports
  • Has a kid’s menu


The atmosphere of the restaurant was inviting and warm. I felt right at home as soon as I walked in the door and was immediately welcomed by the friendly staff.

The pizza was absolutely delicious. The crust was perfectly cooked, with a hint of garlic that gave it just the right amount of flavor. The cheese was melted to perfection and full of flavor. The toppings were fresh and generous – no skimping here!

I also had their famous garlic knots, which were heavenly! They were soft and light, with just the right amount of garlic flavoring. They paired perfectly with my pizza for a truly delightful experience.

Overall, I found Twin Trees Restaurant to be an excellent place to enjoy some of the best pizza in Syracuse NY! If you’re ever in town and need a great meal, look no further than Twin Trees Restaurant – you won’t be disappointed!

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